Drug Repurposing for Rare Diseases

Currently, there are about 7000 identified rare diseases, together affecting 10% of the population. However, fewer than 6% all diseases have an approved treatment option, highlighting their tremendous unmet needs in drug development. The process repurposing drugs for new indications, compared with development novel orphan drugs, is a time-saving and cost-efficient method resulting higher success rates, which can therefore drastically reduce risk diseases. Although not novel, strategies been developed recent years to do it systematic rational way. Here, we review applied methodologies, accomplished progress, challenges associated